Insulin Resistance; is it an Actual Pathologic Compromise of Cellular Integrity or it is just a Potential Toxic Influence on Cellular Function

Abstract

Aim: Demonstration of a possible co-incident toxic influence on cellular function leading to a potential insulin resistance rather than it is an actual permanent compromise of cellular integrity. Background: The spread of DM is rising all over the world in a dramatic way same as the fire spreading in hey especially in developing countries giving the term "diabetic epidemic" an actual credibility. The late three decades demonstrated grave antibiotic aggression towards the stomach bacterium Helicobacter pylori. H. pylori could be forced to migrate to the colon under the influence of the antibiotic violence with consequent accumulation of profuse toxic amounts of colonic ammonia unopposed or buffered by any acidity leading to a biological toxic stress to the body that could predispose to toxic pancreatitis and stress diabetes among those disadvantaged susceptible population. In the same manner, a toxic influence on cellular function could also develop leading to a sort of insulin resistance. Design: A Prospective multiple-case clinical study. Methods: A potent natural colon clear was done for insulin-dependent diabetic patients developing insulin resistance. Results: Response of most patients for insulin administration markedly recovered. Conclusion: The challenge of insulin resistance might be just a potential toxic influence on cellular function rather it is an actual permanent compromise of cellular integrity.