Insulin Resistance; Is It an Actual Pathologic Compromise of Cellular Integrity or It is Just A
Potential Toxic Influence on Cellular Function!!
Abdullah Nasrat Zaitona Medical Center
Abstract
The widespread prevalence and the challenges constituted by Helicobacter pylori; namely its close relation to acid peptic disease, gastric carcinoma and lymphoma have led to the widely-established medical concept that H. pylori eradication should be a necessary attempt. Although eradication regimens do eradicate H. pylori from the stomach; the emergence of antibiotic-resistant H. pylori strains, the severe side effects and the high costs are major drawbacks of these treatments.1 More efficient, economic and friendly drugs need to be developed.
The latest reports in literature demonstrate a definite flare up of many medical challenges strictly related to H. pylori existence through immune or different unknown reasons. Autoimmune thyroiditis, autoimmune pancreatitis, idiopathic thrombocytopenic purpura and acute inflammatory demyelinating polyradiculoneuropathy (Guillian-Barre Syndrome) are examples of these challenges.2 The flare up of these H. pylori-related medical challenges is sufficient to denote that the current combined antibiotic eradication strategies are inadequate to control all the problems associated with the stomach bug.
H. pylori colonized the stomach since an immemorial time;2 as if both the stomach and the bug used to live together in peace, harmless to each other.
References
1. Volk WA, Gebhardt BM, Hammarskjold M-L, Kadner RJ. Essential of Medical Microbiology. Lippincott –
Raven. 1996; 5th Ed: 377.
2. Farinha P, Gascoyne RD. Helicobacter pylori and MALT Lymphoma. Gastroenterology 2005 May; 128(6) : 1579-605.