Validation of a Spectrophotometric Method of Some Antidepressant Drugs

Authors

  • Cadar Emin "Ovidius University of Constanta, Faculty of Pharmacy, Romania"
  • Sirbu Rodica "University of Medicine, Pharmacy ”Carol Davila”, Romania "
  • Ana Maria Ionescu "“Ovidius” University of Constanta, Faculty of Medicine, Romania"
  • Anca Safta "County Clinical Emergency Hospital ”Sf. Ap. Andrei”, Constanta, Romania"
  • Cezar Laurentiu Tomescu "Ovidius University of Constanta, Faculty of Medicine, County Clinical Emergency Hospital ”Sf. Ap. Andrei”, Romania"

Keywords:

validation of method, antidepressant drugs, spectrophotometric

Abstract

Although the causes of depression include a wide range of conditions, from neurodegenerative to thyroid, they all have one common denominator, changes in the brain. Depression can be located in multiple brain regions simultaneously, which may be derived from a common molecular abnormality found in neurons in many brain regions. Abnormalities of receptors or impulse transmission could be the answer. In this work, a simple and accurate spectrophotometric method was developed for the analysis of escitalopram oxalate in various pharmaceutical formulations. In this method, absorbance was measured at 238 nm for escitalopram oxalate. Method validation parameters were studied. The method can be used for quality control of pharmaceutical forms containing escitalopram. Also, by the same method, the actual active substance concentrations compared to those listed on the package, the standard deviations and the relative standard deviations.

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Published

2022-11-24

How to Cite

Emin, C. ., Rodica, S. ., Ionescu, A. M. ., Safta , A. ., & Tomescu, C. L. . (2022). Validation of a Spectrophotometric Method of Some Antidepressant Drugs . European Journal of Medicine and Natural Sciences, 6(1), 1–9. Retrieved from https://revistia.com/index.php/ejmn/article/view/6895